Biochemistry, first class
BSc (Hons) Biochemistry with Professional Placement, University of Bath. Early lab work on cell signalling, mTOR and ERK pathways in papers published in eLife and PNAS.
Doctor. Researcher. Movement coach.
Ed Caddye works where biochemistry, psychiatry and physical capacity meet. The point is practical: for people who are in pain, stuck in recovery or flat in performance, help them understand their body well enough to work on it, alongside their medical care and never in place of it.
A first-class biochemist, a doctor training in psychiatry, and a research fellow imaging brain lactate under load. Also a movement coach for people who have tried the scan, the stretch and the specialist, and still can't get back to what they love.
He is listed by HOMe/HOPe as the first medical doctor in the UK to train in Health Optimization Medicine, under its founder Dr Ted Achacoso, and teaches movement through Moved Academy.
The approach is not about finding as many things ‘wrong’ as possible. It is about understanding what someone can already do well, what may be limiting them, and which physical qualities are genuinely worth developing. The goal is to distinguish interesting findings from the few things that are actually worth working on.
Background
The training behind the work.
Medicine and psychiatry
MB BCh BAO, Queen's University Belfast. PGCert Psychiatry with distinction, Brighton and Sussex Medical School. Core psychiatry training across adult, old age and immunopsychiatry services.
Metabolic psychiatry research
Clinical Research Fellow in Imaging at the Clinical Imaging Sciences Centre, University of Sussex. Doctoral research in clinical neuroscience and metabolic psychiatry, with lactate as a central focus.
Health optimisation practice
The first medical doctor in the UK to train in Health Optimization Medicine, taught by its founder Dr Ted Achacoso. Teaches movement through Moved Academy. Private work with athletes and professionals who want a clearer view of what is worth developing.
Research
Lactate, brain energy, and the cell's decision systems.
Recent work asks how the brain handles metabolic demand under stress. Earlier papers sit in the cell biology of growth and nutrient sensing.
2026 First author
Functional MRS uncovers age-related alterations in cerebral lactate dynamics during emotional-cognitive engagement
Journal of Cerebral Blood Flow & Metabolism
Tracking brain lactate during a graded emotional task, Ed's team found it rose with intensity and peaked higher in older adults. A practical way to stress-test brain energy rather than rely on a single resting scan.
Read the publication 2023 First author
Lactate: a theranostic biomarker for metabolic psychiatry?
Antioxidants
A review arguing that lactate is both a marker and a target in psychiatric care, sitting at the junction of metabolism, inflammation and arousal, and why functional MRS is a good way to watch it change.
Read the publication 2026 Co-author
The airways to alteration (A2A) trial: breathwork-induced altered states of consciousness
Frontiers in Psychology
An exploratory trial where high-ventilation breathwork produced larger acute effects than meditation, with more reported insight a week later. Early work on how breathing shifts brain-body state.
Read the publication 2025 First author
Successful non-surgical management of chronic hip pain in the context of Otto's disease by targeted retraining of the internal torque chain and psoas major
ResearchHub
A published case report on one patient with chronic hip pain who was retrained through targeted, breathwork-integrated movement work rather than proceeding to a planned hip replacement, and who remained improved at two and a half years. A single documented case, not a predictor of individual results.
Read the publication 2016 Co-author
The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids
eLife
From the biochemistry years: ZNRF2 helps mTORC1 sense amino acids and switch on, so losing it shrinks cells and slows growth. Cellular metabolism at close range.
Read the publication 2017 Co-author
Dual-specificity phosphatase 5 controls the localized inhibition, propagation, and transforming potential of ERK signaling
Proceedings of the National Academy of Sciences
DUSP5 was thought to simply switch ERK off in the nucleus. This shows nuclear restraint can instead prolong ERK activity elsewhere, with consequences for how BRAF drives growth.
Read the publication 2014 Co-author
Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer
Proceedings of the National Academy of Sciences
Mice lacking DUSP5 were far more prone to Ras-driven skin tumours. Early evidence of Ed's interest in how cells decide when to grow, stop or tip into disease.
Read the publicationIn practice
What this looks like with clients.
When a joint looks like the whole story
People often arrive having been told a joint is worn out and that surgery may be the only option. Ed starts with different questions: how well is the area being loaded and controlled, and what physical capacity has been lost around it? Sometimes that reframes the picture and sometimes it does not, and any decision about surgery always stays with the treating specialists.
When the limitation isn’t only where it hurts
A pattern Ed sees often is discomfort in one area alongside limitations elsewhere, such as reduced capacity after earlier stress or surgery. The work is to understand what someone can already do well, what may be limiting them, and which physical qualities are genuinely worth developing. Anything that could be a medical red flag is referred for assessment first.
Why hip and back cases keep showing up
People arrive having been told the joint is the problem, or that surgery is the end of the road. Ed often explores whether previous pain or injury has changed how confidently someone moves, loads or uses an area, and whether recovery can support the work. That is often where progress got stuck.
Same mind for brain and body
The lactate research and the movement practice are not separate hobbies. Both ask how energy, signal and demand line up under load. In one setting the load is a scanner task. In the other it is a golf swing, a run, or a week of leadership stress.
Work with Ed
Start with a short note.
Capacity is limited. Send a brief outline of your history and what you want to change, and the team will reply with the most useful next step.
Get in touch