A little about
how I think.

I’m Ed. My background brings together medicine, biochemistry, neuroscience and a longstanding curiosity about how we move.

I work with people who want to understand their movement more deeply, develop their physical capacity, or explore something that hasn’t responded to the obvious answers.

I trained in Health Optimisation Medicine under its founder, Dr Ted Achacoso, and teach movement through Moved Academy. You can find more about that background on the HOMe/HOPe faculty page.

That experience informs my perspective. The service here is movement and performance coaching: observing how you move, experimenting together and finding a manageable set of priorities.

My medical and research work sits alongside this practice. A movement assessment is not a medical consultation, and I recognise when someone needs a different kind of support.

Dr Ed Caddye
Dr Ed Caddye

Background

The training behind the work.

01

Biochemistry, first class

BSc (Hons) Biochemistry with Professional Placement, University of Bath. Early lab work on cell signalling, mTOR and ERK pathways in papers published in eLife and PNAS.

02

Medicine and psychiatry

MB BCh BAO, Queen's University Belfast. PGCert Psychiatry with distinction, Brighton and Sussex Medical School. Core psychiatry training across adult, old age and immunopsychiatry services.

03

Metabolic psychiatry research

Clinical Research Fellow in Imaging at the Clinical Imaging Sciences Centre, University of Sussex. Doctoral research in clinical neuroscience and metabolic psychiatry, with lactate as a central focus.

04

Health optimisation practice

The first medical doctor in the UK to train in Health Optimization Medicine, taught by its founder Dr Ted Achacoso. Teaches movement through Moved Academy. Private work with athletes and professionals who want a clearer view of what is worth developing.

Research

Lactate, brain energy, and the cell's decision systems.

Recent work asks how the brain handles metabolic demand under stress. Earlier papers sit in the cell biology of growth and nutrient sensing.

2026 First author

Functional MRS uncovers age-related alterations in cerebral lactate dynamics during emotional-cognitive engagement

Journal of Cerebral Blood Flow & Metabolism

Tracking brain lactate during a graded emotional task, Ed's team found it rose with intensity and peaked higher in older adults. A practical way to stress-test brain energy rather than rely on a single resting scan.

Read the publication
2023 First author

Lactate: a theranostic biomarker for metabolic psychiatry?

Antioxidants

A review arguing that lactate is both a marker and a target in psychiatric care, sitting at the junction of metabolism, inflammation and arousal, and why functional MRS is a good way to watch it change.

Read the publication
2026 Co-author

The airways to alteration (A2A) trial: breathwork-induced altered states of consciousness

Frontiers in Psychology

An exploratory trial where high-ventilation breathwork produced larger acute effects than meditation, with more reported insight a week later. Early work on how breathing shifts brain-body state.

Read the publication
2025 First author

Successful non-surgical management of chronic hip pain in the context of Otto's disease by targeted retraining of the internal torque chain and psoas major

ResearchHub

A published case report on one patient with chronic hip pain who was retrained through targeted, breathwork-integrated movement work rather than proceeding to a planned hip replacement, and who remained improved at two and a half years. A single documented case, not a predictor of individual results.

Read the publication
2016 Co-author

The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids

eLife

From the biochemistry years: ZNRF2 helps mTORC1 sense amino acids and switch on, so losing it shrinks cells and slows growth. Cellular metabolism at close range.

Read the publication
2017 Co-author

Dual-specificity phosphatase 5 controls the localized inhibition, propagation, and transforming potential of ERK signaling

Proceedings of the National Academy of Sciences

DUSP5 was thought to simply switch ERK off in the nucleus. This shows nuclear restraint can instead prolong ERK activity elsewhere, with consequences for how BRAF drives growth.

Read the publication
2014 Co-author

Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer

Proceedings of the National Academy of Sciences

Mice lacking DUSP5 were far more prone to Ras-driven skin tumours. Early evidence of Ed's interest in how cells decide when to grow, stop or tip into disease.

Read the publication

Work with Ed

Start with a short note.

Tell me what you would like to work on, and we’ll talk through whether a movement assessment is the right place to start.

Get in touch